Apply These Secret Techniques To Improve Pregnancy Loss And Chromosome Testing For Miscarriages

NevilleBruno 27 Mar , 2021 0 Comments Uncategorized

Although most couples are blissfully unaware of the statistics surrounding miscarriage, pregnancy loss is actually quite common, with 10-25% of recognized pregnancies ending in miscarriage. If you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you might be wondering what caused losing and worry about whether it’ll happen again. This short article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
Which kind of genetic testing is available for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different reasons why miscarriage occurs, but the most typical cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also called “aneuploidy” – occur because of a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and then the sex chromosomes, X and Y). For a child to develop normally it is essential that it have exactly the right quantity of chromosome material; missing or extra material at the time of conception or within an embryo or fetus can cause a woman to either not get pregnant, miscarry, or have a child with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are due to chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep increase in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is far more common than most people think. Up to one atlanta divorce attorneys four recognized pregnancies is lost in first trimester miscarriage. The chance of experiencing a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage continue to have a healthy pregnancy and never miscarry again. However, some women appear to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage seems to be increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates in the last decade, whereas previously the miscarriage would have appeared to be just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Helpful for Miscarriages

Genetic testing actually refers to many different types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), probably the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also known as chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are due to aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is called karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, a process called “cell culture”. Due to this requirement, tissue that’s passed at home is often unable to be tested with this particular method. About 20% or more of miscarriage samples neglect to grow and thus no email address details are available. Additionally, karyotyping is unable to tell the difference between cells from the mother (maternal cells) and cells from the fetus. In case a normal female result is found, it may be the right result for the fetus or it can be maternal cell contamination (MCC) where the result actually originates from testing the mother’s cells within the pregnancy tissue rather than the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually take a few weeks to months to come back from the laboratory.

Microarray testing is really a new kind of genetic testing done on miscarriage samples; the two most common types of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also able to test all 23 pairs of chromosomes for aneuploidy, but does not require cell culture. Therefore, you are more likely to receive results and the outcomes are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting an example of the mother’s blood concurrently the miscarriage tissue is delivered to enable immediate detection of maternal cell contamination (MCC).

pregnancy loss Chromosome Testing – How do it help?

In case a chromosome abnormality is identified, the sort of abnormality found could be assessed to help answer fully the question: “Will this happen to me again?”. More often than not, chromosome abnormalities within an embryo or fetus are not inherited and have a low possiblity to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your doctor to do further studies to investigate the possibility of an underlying genetic or chromosome problem in your loved ones that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the need for other, sometimes quite costly, studies your doctor might consider to investigate the reason for the miscarriage.

Lastly, knowing the explanation for a pregnancy loss might help a couple of start the emotional healing up process, moving past the question of “Why did this happen to me?”.

Chromosome testing can be especially very important to patients with repeated miscarriages, as it could either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason behind the miscarriages and invite their doctor to pursue other types of testing. For couples with multiple miscarriages determined to have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing may be able to help increase their likelihood of having an effective healthy pregnancy.

Written By NevilleBruno