Apply These Secret WAYS TO Improve Pregnancy Loss And Chromosome Testing For Miscarriages

NevilleBruno 27 Mar , 2021 0 Comments Uncategorized

Although most couples are blissfully unacquainted with the statistics surrounding miscarriage, pregnancy loss is really quite common, with 10-25% of recognized pregnancies ending in miscarriage. Assuming you have suffered a pregnancy loss or are currently in the process of experiencing a miscarriage, you may be wondering what caused the loss and worry about whether it will happen again. This article aims to answer the following questions:

What causes miscarriage?
How common is pregnancy loss?
What sort of genetic testing is available for miscarriage tissue?
How do chromosome testing help?
Causes of Miscarriage

There are many different explanations why miscarriage occurs, but the most common cause for first trimester miscarriage is a chromosome abnormality. Chromosome abnormalities – extra or missing whole chromosomes, also known as “aneuploidy” – occur due to a mis-division of the chromosomes in the egg or sperm involved with a conception. Typically, humans have 46 chromosomes that come in 23 pairs (22 pairs numbered from 1 to 22 and the sex chromosomes, X and Y). For a child to develop normally it is necessary that it have exactly the right level of chromosome material; missing or extra material during conception or in an embryo or fetus could cause a woman to either not get pregnant, miscarry, or have a baby with a chromosome syndrome such as for example Down syndrome.

Over 50% of most first trimester miscarriages are caused by chromosome abnormalities. This number could be closer to 75% or more for women aged 35 years and over who’ve experienced recurrent pregnancy loss. Overall, the rate of chromosome abnormalities and the rate of miscarriage both increase with maternal age, with a steep upsurge in women older than 35.

Pregnancy Loss – How Common is it?

Miscarriage is a lot more common than a lot of people think. Up to one in every four recognized pregnancies is lost in first trimester miscarriage. The chance of having a miscarriage also increases as a mother gets older.

Most women who experience a miscarriage go on to have a healthy pregnancy and never miscarry again. However, some women seem to be more prone to miscarriage than others. About five percent of fertile couples will experience two or more miscarriages.

Of note, the rate of miscarriage is apparently increasing. One reason for this can be awareness – more women know they are having a miscarriage because home pregnancy tests have improved early pregnancy detection rates over the past decade, whereas during the past the miscarriage would have were just an unusual period. Another reason could be that more women are conceiving at older ages.

Types of Genetic Testing Ideal for Miscarriages

Genetic testing actually identifies many types of testing that you can do on the DNA in a cell. For miscarriage tissue, also called products of conception (POC), the most useful type of test to execute is a chromosome analysis. A chromosome analysis (also called chromosome testing) can examine all 23 pairs of chromosomes for the presence of extra or missing chromosome material (aneuploidy). Because so many miscarriages are caused by aneuploidy, chromosome analysis on the miscarriage tissue could identify the reason behind the pregnancy loss.

The most common method of chromosome analysis is named karyotyping. Newer methods include advanced technologies such as microarrays.

Karyotyping analyzes all 23 pairs of chromosome but requires cells from the miscarriage tissue to first be grown in the laboratory, an activity called “cell culture”. For this reason requirement, tissue that is passed at home is often unable to be tested with this method. About 20% or more of miscarriage samples fail to grow and thus no results are available. Additionally, karyotyping is unable to tell the difference between cells from mom (maternal cells) and cells from the fetus. If a normal female result is found, it may be the correct result for the fetus or it may be maternal cell contamination (MCC) in which the result actually comes from testing the mother’s cells present in the pregnancy tissue instead of the fetal cells. MCC appears to occur in about 30% or even more of the samples tested by traditional karyotype. Results from karyotyping usually have a few weeks to months another from the laboratory.

Microarray testing is a new kind of genetic testing done on miscarriage samples; both most common forms of microarray testing are array CGH (comparative genomic hybridization) and chromosome SNP (single-nucleotide polymorphism) microarray. Microarray testing is also in a position to test all 23 pairs of chromosomes for aneuploidy, but will not require cell culture. Therefore, you are more likely to receive results and the results are usually returned faster when microarray testing can be used. Additionally, some laboratories are collecting a sample of the mother’s blood at the same time the miscarriage tissue is sent to enable immediate detection of maternal cell contamination (MCC).

Chromosome Testing – How can it help?

In case a chromosome abnormality is identified, the sort of abnormality found can be assessed to help answer fully the question: “Will this eventually me again?”. stillbirth Quite often, chromosome abnormalities in an embryo or fetus aren’t inherited and have a minimal chance to occur in future pregnancies. Sometimes, a particular chromosome finding in a miscarriage alerts your physician to do further studies to research the possibility of an underlying genetic or chromosome problem in your loved ones that predisposes one to have miscarriages.

Furthermore, if a chromosome abnormality is identified it can prevent the dependence on other, sometimes quite costly, studies your physician might consider to investigate the cause of the miscarriage.

Lastly, knowing the reason behind a pregnancy loss can help a couple start the emotional healing process, moving at night question of “Why did this eventually me?”.

Chromosome testing can be especially important for patients with repeated miscarriages, as it can either give clues to an underlying chromosomal cause for the miscarriages or eliminate chromosome errors as the reason for the miscarriages and allow their doctor to pursue other types of testing. For couples with multiple miscarriages determined to truly have a chromosomal cause, in vitro fertilization (IVF) with preimplantation genetic diagnosis (PGD) testing might be able to help increase their likelihood of having an effective healthy pregnancy.

Written By NevilleBruno